ABSTRACT
Background: A novel coronavirus COVID-19 outbreak causing infectious respiratory disorders. COVID-19 disease has no specific treatment. In traditional medicinal system, different formulations are available for infectious diseases. Objective(s): This review discusses the significance and utilization of Siddha and Ayurvedic herbal formulations for COVID-19 treatment and provides scientific information regarding the phytochem-istry and pharmacological profiles of Indian medicinal plants used in the formulation. Method(s): The information on medicine and medicinal plants was collected from research papers, review papers, and books available in several electronic databases, including Google Scholar, SpringerLink, and PubMed was explored as information sources. Result(s): Traditional medicinal plants are potentially used in formulations due to their inevitable therapeutic properties. Phytochemistry and pharmacological properties of medicinal plants used in the formulations served as scientific proof for traditional medicine. Conclusion(s): The present study explored the great importance of Siddha and Ayurvedic formulations for COVID-19 treatment. Further scientific investigations are required to explore these formulations as widely acceptable.Copyright © 2023 Bentham Science Publishers.
ABSTRACT
Kabasura Kudineer is a polyherbal decoction of the Siddha medical system (an Indian system of medicine), traditionally used to cure fever, colds, coughs, and respiratory ailments. The government of India had recommended Kabasura Kudineer as one of many preventive/treatment measures for COVID-19. Kabasura Kudineer Choornam is an admixed coarse powder of 15 herbs and its decoction is Kabasura Kudineer. The chemical constituents in the 15 herbs used for the preparation of the Choornam are known but the constituents present in the Kabasura Kudineer (decoction) are unidentified. Piperine, vasicine and eugenol are known for their potent activity against respiratory tract infections;hence, they were selected as marker compounds. The present work was planned to simultaneously quantify piperine, vasicine and eugenol in Kabasura Kudineer by the HPTLC method. The optimised mobile phase was toluene: ethyl acetate: methanol: ammonia (5:9:3:0.5, v/v/v/v), and the scanning was carried out at 287 nm. The Rf values of piperine, vasicine and eugenol were found to be 0.70, 0.32 and 0.82, respectively. The linearity range of piperine and vasicine was 500-3000 ng spot-1 and it was 10-60 ng spot-1 for eugenol. The quantities of piperine, vasicine and eugenol in Kabasura Kudineer (100 mL) were 0.03, 0.056 and 0.035 % w/v, respectively. This developed method can be used to simultaneously quantify piperine, vasicine and eugenol in any polyherbal formulation.Copyright © 2023, Informatics Publishing Limited and Society for Biocontrol Advancement. All rights reserved.
ABSTRACT
Introduction: Kabasura kudineer is a concoction prepared as a siddha product which is effective against respiratory infection (1). It is made with the use of 15 herbs which includes ginger, clove, Piper Longum, Dusparsha, Akarakarabha, Kokilaksha, haritaki, Malabar nut, ajwain, Kusta, guduchi, Kalamegha,Raja pata, musta and Bharani (2). Each and every ingredient has its own importance like ginger promotes digestion and helps in treatment of respiratory ailments (3), Pippalli can treat indigestion, asthma and cough, clove helps to kill bacteria and promote liver health etc. Thus the aim of the study is to analyze the knowledge and awareness on the role of Kabasura kudineer on immunity among the adult population. Materials and methods: Self-administered structured questionnaires were designed based on the knowledge and awareness of the role of Kabasura kudineer on immunity among adults. The questionnaire was distributed through online google forms link, the study population included 100 dental students in Chennai.The data was collected and statistically analysed in SPSS of version 26.0.The study was approved by the Institutional Review Board. Results: Majority of 19 year old (52%) individuals had responded whereas 35% of 17 year old respondents among them nearly 97% were females and 88% were aware of kabasura kudineer. It was appreciable that 83% of respondents were aware that kabasura kudineer was a siddha formulation and only 50% were aware it was administered as concoction among whom 78% of individuals knew that it is a perfect remedy for respiratory ailments. Majority (52%) respondents were aware about the herbal ingredients used. Conclusion: Thus majority of adults were not aware about the properties of Kabasura kudineer. More awareness programmes have to be done to make Kabasura kudineer a prophylactic agent world wide.
ABSTRACT
BACKGROUND: Kabasura Kudineer (KSK) is a Siddha polyherbal decoction recommended by the Ministry of AYUSH and the Tamil Nadu government to prevent and manage COVID-19 in India. OBJECTIVES: We aimed to determine the outcome of integrated therapy for COVID-19 using KSK in virologic clearance and length of hospital stay. MATERIALS AND METHODS: It was a single-centre, retrospective cohort study. We included the COVID-19 patients admitted to SRM Medical College Hospital and Research Centre, Chennai, during May-June 2020. KSK was administered along with the standard of care for all the patients. We collected data pertaining to demographic, clinical, and laboratory parameters and presented as frequencies and proportions. RESULTS: We collected 204 COVID-19 positive patients' data. The mean (SD) age was 39.5 (13.4) years with a range of 13-79. Majority of the patients were male (n = 157; 77%), 28% (n = 58) had any co-morbidities, and 61% (n = 131) had mild symptoms. Fever (n = 57; 27.9%) and cough (n = 53; 25.9%) were the commonly reported symptoms. Paracetamol (n = 135; 66.7%) and Zincovit (n = 197, 96.6%) were the commonly administered medicines along with KSK. About 74% of asymptomatic (n = 54) and 65% of mild symptomatic (n = 85) patients turned negative for COVID-19 in RT-PCR within 4-7 days. There was a significant difference in the blood parameters (p < 0.05) after the integrated treatment. CONCLUSION: The use of KSK with standard care of treatment in COVID-19 treatment had notable results in the duration taken for virologic clearance, thereby reducing the length of hospital stay and improvement in laboratory parameters.
ABSTRACT
Background: This study has been conducted on confirmed COVID 19 positive patients (n = 55), who had come to Kallakurichi District of Tamilnadu state from one of the containment zones in Indian State of Maharashtra. Out of the 55, 8 (14.55%) patients were symptomatic and remaining 47 (85.45%) were asymptomatic patients. 47 patients who reached in their home land on 24th May and rest on 25th may 2020. All of them have been treated with integrated medicine treatment method. Materials and Methods: Everybody was quarantined from 27th may to 7th June 2020 at Mahabharathi Engineering College, Vasudevanur, Chinna salem Taluk, Kallakurichi District. Integrative Intervention Consisting of Vitamin C Tablet, Zinc tablet for 5 days, and Kabasura Kudineer 60 ml BD Before food for all days was the treatment given for all patients. Result: Among them, three of them had co -morbid conditions like diabetes and hypertension. 27.3% were female and 72.7% are male patients. Average age was 32.33 among the range of 14 to 65years. Conclusion: All patients including who has co-morbidity were completely relieved from the disease on the day of discharge. All symptomatic patients were asymptomatic with median time of 4 days IP admission.
ABSTRACT
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a single-stranded RNA virus that causes SARS. The virus was originally called SARS-CoV-2 named officially by the World Health Organization as COVID-19 and a global health emergency. Aim: The aim of this article is to assess various clinical findings, comorbidities, and outcomes including periods of hospital stay of asymptomatic/symptomatic COVID-19 patients admitted at the Government Medical College, Omandurar, Chennai District of Tamil Nadu state and those who were under Integrated Medical care of hydroxychloroquine and Kabasura Kudineer. Materials and Methods: This study is a retrospective cross-sectional study on 162 asymptomatic/symptomatic laboratory-confirmed SARS-CoV-2-infected patients from both sexes and all age groups, admitted to the Government Medical College, Omandurar, Chennai District of Tamil Nadu state, India from March 30, 2020 to April 30, 2020. Results: SARS-CoV-2 confirmed 162 patients: 114 (70.4%) males and 48 (29.6%) females participated in the study. About 37.7% of the participants belonged to the age group of 26–40 years, 32.7% belonged to the age group 41–60 years, 16% belonged to the age group 13–25 years, 9.9% belonged to the age group greater than 60 years, and 3.7% belonged to the age group of 0–12 years. Around 16.7% have comorbidities, whereas the remaining 83.3% were free from comorbid conditions. All participants were given Kabasura Kudineer, but the treatment of allopathy medicine intake varies from person to person depending on their health status and disease severity. Abdominal computed tomography scan or chest X-rays of 24 (14.8%) patients were done during the study period. Two patients died and two were referred to another hospital, remaining 97.5% completely recovered from the viral infection. Admission days varied from 1 to 23 days. The overall median length of stay was 16 days based on this study. Conclusion: This study reveals that 97.5% of the patients were completely recovered from the viral infection and both average and median hospital stay is 16 days.
ABSTRACT
Background: COVID-19 viral infection is a worldwide pandemic that created a major concern regarding the need for a suitable drug candidate for viral infections. The entire scientific community is putting up their efforts and research to find a proper cure for this. The traditional Indian Siddha system of medicine is one of the oldest forms of medicine, which includes medicine, Varma, alchemy, yoga, and rejuvenation. Method(s): Kabasura kudineer is one of the Siddha herbal preparations that are being recommended by the State government of Tamilnadu, India, for protection against COVID-19. It is recommended due to its claims to have anti-viral properties and other numerous health benefits. Result(s): This article thoroughly examines the Kabasura kudineer, a polyherbal formulation comprising 15 powerful ancient Indian herbals that possess various potential phytochemicals providing numerous therapeutic activities. Also, the review highlights the most important therapeutic benefits of this formulation like anti-viral properties along with other activities such as im-munomodulatory, bronchodilatory, anti-asthmatic, etc., Conclusion(s): The role of Kabasura kudineer against viral diseases, especially the recent COVID-19, is tremendous, and there is a need to enhance further research on this powerful formulation to make it more efficient and useful to the entire people community. Copyright © 2022 Bentham Science Publishers.
ABSTRACT
Background: Siddha Medicine is a valuable therapeutic choice which is classically used for treating viral respiratory infections, this principle of medicine is proven to contain antiviral compounds. Objective: The study is aimed to execute the In Silico computational studies of phytoconstituents of Siddha official formulation Kabasura Kudineer and novel herbal preparation JACOM which are commonly used in treating viral fever and respiratory infectious diseases and could be affective against the ongoing pandemic novel corona virus disease SARS-CoV-2. Method: Cresset Flare software was used for molecular docking studies against the spike protein SARSCoV-2 (PDB ID: 6VSB). Further, we also conducted in silico prediction studies on the pharmacokinetics (ADME) properties and the safety profile in order to identify the best drug candidates by using online pkCSM and SwissADME web servers. Results: Totally 37 compounds were screened, of these 9 compounds showed high binding affinity against SARS-CoV-2 spike protein. All the phytoconstituents were free from carcinogenic and tumorigenic properties. Based on these, we proposed the new formulation called as "SNACKeV" Conclusion: Based on further experiments and clinical trials, these formulations could be used for effective treatment of COVID-19. (c) 2020 The Authors. Published by Elsevier B.V. on behalf of Institute of Transdisciplinary Health Sciences and Technology and World Ayurveda Foundation. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
ABSTRACT
Novel coronavirus pneumonia (COVID-19) is a respiratory infection caused by infecting lungs and respiratory pathways which has rapidly spread to 216 countries. It is causing serious harm to the world's entire population and a huge social burden, which can spread mainly by droplets produced during coughing and sneezing from animal to animal or human to human. There were no drugs or vaccines available as of May 2020. Though the severity and infectious behavior and mortality rate of COVID-19 led to the discovery of various vaccines and drugs that are available to control COVID-19 pandemic. India has two vaccines: Covishield and Covaxin approved by the Government of India on 2nd January 2021. Of this sudden and lethal disease, the traditional Indian siddha medicine was proficient as an alternative source, in performing differentiation with fewer side effects and better ability to prevent and control. In this article, we have comprehensively analyzed the case study and the efficacy of Indian Siddha medicine Kabasura Kudineer chooranam. Naturally occurring Indian Siddha medicinal (Kabasura Kudineer chooranam) compounds and its treatment as prevention measures so as to provide strategy and suggestions for the disease COVID-19 are discussed.
ABSTRACT
Introduction: Non-tested asymptomatic COVID-19 cases poses threat of transmitting the disease silently. The Siddha polyherbal formulation, hnology Kabasurakudineer, (KSK) was found to be effective in preventing viral replication of SARS-CoV-2 by in-silico studies. A pilot study was conducted to test the antiviral activity of KSK in asymptomatic individuals tested positive for COVID-19. Methods: A single centre, open labelled, randomized controlled study was carried out during June-August 2020, in Tertiary Medical College Hospital, after approval from the institutional ethics committee and registered in CTRI. RTPCR confirmed COVID-19 asymptomatic cases, aged 18-65 years, consented to participate were . included and those with co-morbidities like diabetes, hypertension, severe respiratory disease, malignancies, pregnant and lactating mothers were excluded. Hospitals of Semnan Uniiessi y 60 participants were randomly assigned to study and control group. Study group received KSK (60 ml) along with vitamin C in the morning and zinc in the night, while the control group (CZ) received vitamin C and zinc for 10 days. The primary outcome was the reduction in the SARS-CoV-2 load (ct value), prevention of progression to symptomatic state. Results: In the study group, there was faster reduction in the viral load in terms of ct value as all the 30 participants turned negative for SARS-Co-V2, while 4 remain positive in the control group on the 10th day. The inflammatory markers and serum cytokine findings were inconclusive. No one progressed to the symptomatic state and no adverse event was reported in either groups. Conclusion: This study demonstrated the potential of Kabasurakudineer in reducing the viral load. Further clinical studies are warranted with larger sample size.
ABSTRACT
Ascorbic acid (AA) and eugenol (EUG) are well-known antioxidants found in several fruits, spices and herbs. In particular, the EUG, one of the major phytocompounds present in clove, acts as pro-oxidant or anti-oxidant depending on its concentration. Considering the medical importance of AA and EUG and its extensive usage in the form of food and medicine, we have developed a voltammetric sensor based on hydroxyapatite-TiO2 composite modified GCE for their selective and simultaneous determination over very wide linear range of 2.78-2490 µM for AA and 1.4-78 µM for EUG with the LODs of 63.3 nM and 94 nM respectively. Practical applicability of the prepared electrode has been demonstrated by detecting AA and EUG in lemon juice, vitamin tablet, clove oil and Kabasura Kudineer, an herbal decoction used as an immunity booster against number of diseases including Covid-19. The proposed HAP-TiO2/GCE shall be useful for food and pharmaceutical industries.
Subject(s)
COVID-19 , Graphite , Nanocomposites , Plants, Medicinal , Ascorbic Acid , Dopamine/analysis , Durapatite , Electrodes , Eugenol , Fruit/chemistry , Pharmaceutical Preparations , TitaniumABSTRACT
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) transmissions are occurring rapidly; it is raising the alarm around the globe. Though vaccines are currently available, the evolution and mutations in the SARS-CoV-2 threaten available vaccines' significance. The drugs are still undergoing clinical trials, and certain medications are approved for "emergency use" or as an "off-label" drug during the pandemic. These drugs have been effective yet accommodating side effects, which also can be lethal. Complementary and alternative medicine is highly demanded since it embraces a holistic approach. Since ancient times, natural products have been used as drugs to treat various diseases in the medical field and are still widely practiced. Medicinal plants contain many active compounds that serve as the key to an effective drug design. The Kabasura kudineer and Nilavembu kudineer are the two most widely approved formulations to treat COVID-19. However, the mechanism of these formulations is not well known. The proposed study used a network pharmacology approach to understand the immune-boosting mechanism by the Kabasura kudineer, Nilavembu kudineer, and JACOM in treating COVID-19. The plants and phytochemical chemical compounds in the Kabasura kudineer, Nilavembu kudineer, and JACOM were obtained from the literature. The Swiss target prediction algorithm was used to predict the targets for these phytochemical compounds. The common genes for the COVID-19 infection and the drug targets were identified. The gene-gene interaction network was constructed to understand the interactions between these common genes and enrichment analyses to determine the biological process, molecular functions, cellular functions, pathways involved, etc. Finally, virtual screening and molecular docking studies were performed to identify the most potential targets and significant phytochemical compounds to treat the COVID-19. The present study identified potential targets as ACE, Cathepsin L, Cathepsin B, Cathepsin K, DPP4, EGFR, HDAC2, IL6, RIPK1, and VEGFA. Similarly, betulinic acid, 5â³-(2â-Hydroxybenzyl) uvarinol, antofine, (S)-1'-methyloctyl caffeate, (Z)-3-phenyl-2-propenal, 7-oxo-10α-cucurbitadienol, and PLX-4720 collectively to be potential treatment agents for COVID-19.
Subject(s)
COVID-19 Drug Treatment , Humans , Immune System , Molecular Docking Simulation , Network Pharmacology , SARS-CoV-2ABSTRACT
There is an urgent need for reliable cure and preventive measures in this hour of the outbreak of SARS-CoV-2. Siddha- and Ayurvedic-based classical formulations have antiviral properties and great potential therapeutic choice in this pandemic situation. In the current study, in silico-based analysis for the binding potential of phytoconstituents from the classical formulations suggested by the Ministry of Ayush (Kabasura Kudineer, Shwas Kuthar Rasa with Kantakari and pippali churna, Talisadi churna) to the interface domain of the SARS-CoV-2 receptor-binding domain and angiotensin-converting enzyme 2 was performed. Maestro software from Schrodinger and tools like Glide Docking, induced fit docking, MM-GBSA, molecular dynamics (MD) simulation, and thermal MM-GBSA was used to analyze the binding of protein PDB ID:6VW1 and the selected 133 ligands in comparison with drug molecules like favipiravir and ribavirin. QikProp-based ADMET evaluation of all the phytoconstituents found them nontoxic and with drug-like properties. Selection of top ten ligands was made based on docking score for further MM-GBSA analysis. After performing IFD of top five molecules iso-chlorogenic acid, taxiphyllin, vasicine, catechin and caffeic acid, MD simulation and thermal MM-GBSA were done. Iso-chlorogenic acid had formed more stable interaction with key residue among all phytoconstituents. Computational-based study has highlighted the potential of the many constituents of traditional medicine to interact with the SARS-CoV-2 RBD and ACE2, which might stop the viral entry into the cell. However, in vivo experiments and clinical trials are necessary for supporting this claim. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11696-021-01917-z.
ABSTRACT
Introduction: Kabasura kudineer is a concoction prepared as a siddha product which is effective against respiratory infection. It is made with the use of 15 herbs which includes ginger, clove, Piper Longum, Dusparsha, Akarakarabha, Kokilaksha, heritage, Malabar nut, ajwain, Kusta, guduchi, Kalamegha, Raja pata, musta and Bharani. Each and every ingredient has its own importance like ginger promotes digestion and helps in treatment of respiratory ailments, Pippalli can treat indigestion, asthma and cough, clove helps to kill bacteria and promote liver health etc. Thus the aim of the study is to analyse the knowledge and awareness on the role of Kabasura kudineer on immunity among the adult population. Materials and methods: Self-administered structured questionnaires were designed based on the knowledge and awareness of the role of Kabasura kudineer on immunity among adults. The questionnaire was distributed through online goggle forms link;the study population included 100 dental students in Chennai. The data was collected and statistically analysed in SPSS of version 26.0.The study was approved by the Institutional Review Board. Results: Majority of 19 year old (52%) individuals had responded whereas 35% of 17 year old respondents among them nearly 97% were females and 88% were aware of kabasura kudineer. It was appreciable that 83% of respondents were aware that kabasura kudineer was a siddha formulation and only 50% were aware it was administered as concoction among which 78% of individuals knew that it is a perfect remedy for respiratory ailments. Majority (52%) respondents were aware about the herbal ingredients used. Conclusion: Thus majority of adults were not aware about the properties of Kabasura kudineer. More awareness programmes have to be done to make Kabasura kudineer a prophylactic agent worldwide.
ABSTRACT
INTRODUCTION: Despite several ongoing efforts in biomedicine and traditional medicine, there are no drugs or vaccines for coronavirus disease 2019 (COVID-19) as of May 2020; Kabasura Kudineer (KSK), a polyherbal formulation from India's Siddha system of medicine, has been traditionally used for clinical presentations similar to that of COVID-19. We explored the efficacy of KSK in reducing viral load and preventing the disease progression in asymptomatic, COVID-19 cases. METHODS: A prospective, single-center, open-labeled, randomized, controlled trial was conducted in a COVID Care Centre in Chennai, India. We recruited reverse-transcription polymerase chain reaction (RT-PCR)-confirmed COVID-19 of 18 to 55 years of age, without clinical symptoms and co-morbidities. They were randomized (1:1 ratio) to KSK (60 mL twice daily for 7 days) or standard of care (7 days supplementation of vitamin C 60,000 IU morning daily and zinc 100 mg evening daily) groups. The primary outcomes were reduction in the SARS-CoV-2 load [as measured by cyclic threshold (CT) value of RT-PCR], prevention of progression of asymptomatic to symptomatic state, and changes in the immunity markers including interleukins (IL-6, IL-10, IL-2), interferon gamma (IFNγ), and tumor necrosis factor (TNF α). Siddha clinical assessment and the occurrence of adverse effects were documented as secondary outcomes. Paired t-test was used in statistical analysis. RESULTS: Viral load in terms of the CT value (RdRp: 95% CI = 1.89 to 5.74) declined significantly on the seventh day in the KSK group and that of the control group, more pronounced in the study group. None progressed to the symptomatic state. There was no significant difference in the biochemical parameters. We did not observe any changes in the Siddha-based clinical examination and adverse events in both groups. CONCLUSION: KSK significantly reduced SARS-CoV-2 viral load among asymptomatic COVID-19 cases and did not record any adverse effect, indicating the use of KSK in the strategy against COVID-19. Larger, multi-centric trials can strengthen the current findings. TRIAL REGISTRATION: Clinical Trial Registry of India CTRI2020/05/025215 . Registered on 16 May 2020.
Subject(s)
COVID-19 , SARS-CoV-2 , Ascorbic Acid , Dietary Supplements , Humans , India , Medicine, Ayurvedic , Prospective Studies , Treatment Outcome , Viral Load , ZincABSTRACT
CONTEXT: During an earlier outbreak of dengue (DENV), chikungunya (CHIKV) and swine flu in Tamil Nadu, India, Kabasura Kudineer and Nilavembu Kudineer were used to control the febrile episodes. No research is conducted in the past to understand the attitude and beliefs of people towards using Kabasura Kudineer as a means to improve immunity in people, especially in Tamil Nadu, the birthplace of Siddha medicine which led the researcher to conduct the study. AIMS: The researcher in the present paper aims to understand the attitude, belief and self-use of Kabasura Kudineer among people in Tamil Nadu, India. SETTINGS AND DESIGN: A cross-sectional questionnaire survey was conducted among various people in Tamilnadu, India wherein data was collected from 200 participants. METHODS AND MATERIAL: A cross-sectional study involving explanatory/descriptive research design was considered for the study. STATISTICAL ANALYSIS USED: For the analysis of collected data statistical package for SPSS software version 25.0 was used. RESULTS: The urban participants who participated in the study were 80.5% and the rural participants were 19.5%. The significant P value (0.002) indicated that people use kabasura kudineer because allopathic medicine is less effective medicine and the significant P value (0.001) shows that kabasura kudineer is taken as a self-medication among Tamil Nadu people. CONCLUSIONS: The findings of the study revealed the better empowerment of people in the select region towards the use of Kabasura Kudineer.
ABSTRACT
The COVID-19 has now been declared a global pandemic by the World Health Organization. No approved drug is currently available; therefore, an urgent need has been developed for any antiviral therapy for COVID-19. Main protease 3CLpro of this novel Coronavirus (SARS-CoV-2) play a critical role in the disease propagation, and hence represent a crucial target for the drug discovery. Herein, we have applied a bioinformatics approach for drug repurposing to identify the possible potent inhibitors of SARS-CoV-2 main proteases 3CLpro (6LU7). In search of the anti-COVID-19 compound, we selected 145 phyto-compounds from Kabasura kudineer (KK), a poly-herbal formulation recommended by AYUSH for COVID-19 which are effective against fever, cough, sore throat, shortness of breath (similar to SARS-CoV2-like symptoms). The present study aims to identify molecules from natural products which may inhibit COVID-19 by acting on the main protease (3CLpro). Obtained results by molecular docking showed that Acetoside (-153.06), Luteolin 7 -rutinoside (-134.6) rutin (-133.06), Chebulagic acid (-124.3), Syrigaresinol (-120.03), Acanthoside (-122.21), Violanthin (-114.9), Andrographidine C (-101.8), myricetin (-99.96), Gingerenone -A (-93.9), Tinosporinone (-83.42), Geraniol (-62.87), Nootkatone (-62.4), Asarianin (-79.94), and Gamma sitosterol (-81.94) are main compounds from KK plants which may inhibit COVID-19 giving the better energy score compared to synthetic drugs. Based on the binding energy score, we suggest that these compounds can be tested against Coronavirus and used to develop effective antiviral drugs.